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Pharmacogenomics (also known as pharmacogenetics) is the study of how our genes affect the way we respond to medications. The word “pharmacogenomics” comes from the words “pharmacology” (the study of the uses and effects of medications) and “genomics” (the study of genes and their functions).
Pharmacogenetics describes how genes influence the metabolism of drugs [44,46]. The field of pharmacogenetics is aimed to identify patients at a higher genetically-determined risk of adverse effects or an inadequate response to medication [9,44–46].
Pharmacogenetics is the discipline that translates information on genetic variability into prediction of the pharmacokinetics (PK) and pharmacodynamics effects of drugs and was assumed to revolutionize pharmacotherapy.
MedlinePlus provides additional details about pharmacogenetic tests.. The National Institute of General Medical Sciences offers a list of Frequently Asked Questions about Pharmacogenomics.. A pharmacogenomics fact sheet and a list of Frequently Asked Questions about Pharmacogenomics is offered by the National Human Genome Research Institute.. Medical Genetics Summaries, provided by the ...
Learn about pharmacogenetics, the variations in drug response due to genetic makeup. Find out how drug metabolism, elimination, and interactions can be influenced by genetic factors and aging.
Pharmacogenomics refers to polygenic drug response phenotypes and encompasses transcriptomics, proteomics, and metabolomics. Mechanisms of pharmacogenetic interactions. Pharmacokinetics involves the absorption, distribution, metabolism, and elimination of pharmaceutics.
The series begins with articles concentrating on individual drug metabolizing enzyme gene polymorphisms, which classically fit in with the term pharmacogenetics. Over the course of the year, broader ‘pharmacogenomic’ articles that concentrate on disease categories, study design and the role of genotyping in clinical trials and clinical ...
PHARMACOGENOMICS: ORIGINS AND DEVELOPMENT. The concept of “pharmacogenetics” was first put forward by the famed American geneticist Arno Moltulsky over a half century ago 4 at a time when it was already becoming clear that variation in drug response could be due, at least in part, to the effects of genetic inheritance. Subsequently, a steady stream of reports appeared that described the ...
Pharmacogenomics looks at how your DNA affects the way you respond to drugs. In some cases, your DNA can affect whether you have a bad reaction to a drug or whether a drug helps you or has no effect. Pharmacogenomics can improve your health by helping you know ahead of time whether a drug is likely to benefit you and be safe for you to take.
Pharmacogenomics is the use of genomic and other “omic” information to individualize drug selection and drug use to avoid adverse drug reactions and to maximize drug efficacy. The science underlying pharmacogenomics has evolved rapidly over the 50 years since it was first suggested that genetics might influence drug response phenotypes.