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Hydroxyzine. Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication. [ 8 ] It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness). [ 8 ] It is used either by mouth or injection into a muscle. [ 8 ]
Lindane. Lindane, also known as gamma-hexachlorocyclohexane (γ-HCH), gammaxene, Gammallin and benzene hexachloride (BHC), [3] is an organochlorine chemical and an isomer of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical treatment for lice and scabies. [4][5]
The drug is approximately 73% protein-bound across a plasma range of 7 to 226 ng/mL (28–892 nM). [1] The metabolism of nefopam is hepatic , by N - demethylation and via other routes . [ 1 ] Its terminal half-life is 3 to 8 hours, while that of its active metabolite , desmethylnefopam, is 10 to 15 hours. [ 1 ]
[28] [16] Daridorexant at a dose of 50 mg (the maximum recommended dose) showed significantly greater drug liking than placebo but significantly less drug liking than zolpidem (30 mg) and suvorexant (150 mg) in recreational sedative drug users.
Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain (angina), heart failure and esophageal spasms. [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers. [2] It is taken by mouth.
Ormeloxifene is a selective estrogen receptor modulator (SERM). In some parts of the body, its action is estrogenic (e.g., bones), in other parts of the body, its action is antiestrogenic (e.g., uterus, breasts). [13][14][15] It causes an asynchrony in the menstrual cycle between ovulation and the development of the uterine lining, although its ...
Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M 1 and M 3 receptors. It is used in the treatment of dry mouth and Sjögren's syndrome.
Dapoxetine is absorbed and distributed rapidly in the body. Greater than 99% of dapoxetine is bound to the plasma protein. The mean steady-state volume is 162 L. Its initial half-life is 1.31 hours (30 mg dose) and 1.42 hours (60 mg dose), and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose). [27] Metabolism