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The transferrin protein binds free iron and transports it in the blood. Total iron-binding capacity ( TIBC) or sometimes transferrin iron-binding capacity is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. [ 1] Transferrin can bind two atoms of ferric iron (Fe 3+) with high affinity.
Structure. In humans, transferrin consists of a polypeptide chain containing 679 amino acids and two carbohydrate chains. The protein is composed of alpha helices and beta sheets that form two domains. [ 18] The N- and C- terminal sequences are represented by globular lobes and between the two lobes is an iron-binding site.
For instance, a value of 15% means that 15% of iron-binding sites of transferrin are being occupied by iron. The three results are usually reported together. A low transferrin saturation is a common indicator of iron deficiency anemia whereas a high transferrin saturation may indicate iron overload or hemochromatosis.
003488. Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin and freely circulate in the blood. Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin ...
Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia. [4] Aggregated ferritin transforms into a toxic form of iron called hemosiderin. [5] Ferritin is a globular protein complex consisting of 24 protein subunits forming a hollow ...
Iron can be stored in ferritin as ferric iron due to the ferroxidase activity of the ferritin heavy chain. [28] Dysfunctional ferritin may accumulate as hemosiderin, which can be problematic in cases of iron overload. [29] The ferritin storage iron pool is much larger than the labile iron pool, ranging in concentration from 0.7 mM to 3.6 mM. [25]
54,200 (2015) [ 7] Iron-deficiency anemia is anemia caused by a lack of iron. [ 3] Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. [ 3] When onset is slow, symptoms are often vague such as feeling tired, weak, short of breath, or having decreased ability to exercise. [ 1]
evaluate iron level. Iron tests are groups of clinical chemistry laboratory blood tests that are used to evaluate body iron stores or the iron level in blood serum . Other terms used for the same tests are iron panel, iron profile, iron indices, iron status or iron studies .
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