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Aromatase inhibitors ( AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, [1] [2] and gynecomastia in men. They may also be used off-label to reduce estrogen conversion when supplementing testosterone exogenously. They may also be used for chemoprevention in women at high risk for breast cancer.
Mary. Joseph [c] Jesus [d] ( c.6 to 4 BC – AD 30 or 33), also referred to as Jesus Christ, [e] Jesus of Nazareth, and many other names and titles, was a first-century Jewish preacher and religious leader. [10] He is the central figure of Christianity, the world's largest religion.
A dopamine agonist(DA) is a compound that activates dopamine receptors. There are two families of dopamine receptors, D 1 -like and D 2 -like. They are all G protein-coupled receptors. D 1 - and D 5 -receptors belong to the D 1 -like family and the D 2 -like family includes D 2, D 3 and D 4 receptors. [1] Dopamine agonists are primarily used in ...
SoftBank Corporation, its spun-out affiliate and former flagship business, is the third-largest wireless carrier in Japan, with 45.621 million subscribers as of March 2021. [23] Poor investment decisions of Masayoshi Son’s SoftBank Group led to a panoply of losing investments across the history of the company.
D.A.R.E. logo. Drug Abuse Resistance Education, or D.A.R.E., is an American education program that tries to prevent use of controlled drugs, membership in gangs, and violent behavior. It was founded in Los Angeles in 1983 as a joint initiative of then- LAPD chief Daryl Gates and the Los Angeles Unified School District [1] [2] as a demand -side ...
Definition United States. According to the US Food and Drug Administration (FDA), an orphan drug is defined as one "intended for the treatment, prevention or diagnosis of a rare disease or condition, which is one that affects less than 200,000 persons in the US" (which equates to approximately 6 cases per 10,000 population) "or meets cost recovery provisions of the act".
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes that catalyze metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs. In humans, it is the CYP2C19 gene that encodes the ...
OTC drugs are usually regulated according to their active pharmaceutical ingredient (API) and strengths of final products. [2] The term over-the-counter ( OTC) refers to a medication that can be purchased without a medical prescription. [3] In contrast, prescription drugs require a prescription from a doctor or other health care professional ...