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Costco membership card from Iceland. Costco's earliest predecessor, Price Club, opened its first store on July 12, 1976, on Morena Boulevard in San Diego, California.It was founded three months earlier by Sol Price and his son, Robert, following a dispute with the new owners of FedMart, Price's previous membership-only discount store. [14]
Levomethadone has a lower affinity, with an IC 50 of ~29 μM at the hERG channel. [60] Methadone is also known to block the Na v 1.5 voltage-gated Na+ channel (SCN5A) with an IC 50 of ~10 μM, which is similar to the local anesthetic bupivacaine. Both enantiomers of methadone block the Na v 1.5 channel with similar affinities. [60]
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